Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6ST | P40189 | 5/20 | 0.53 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.43 |
| ▸ | IDH1 | O75874 | 3/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277218 | 1.00 | IL6ST (0.53) | IL6STSLC15A1IDH1STAT3AVPR1A | |
| SCHEMBL7277227 | 1.00 | IL6ST (0.53) | IL6STSLC15A1IDH1STAT3AVPR1A | |
| SCHEMBL2299086 | 0.88 | IL6ST (0.47) | IL6STSLC15A1IDH1CYP1A2CYP3A4 | |
| SCHEMBL2299084 | 0.88 | IL6ST (0.47) | IL6STSLC15A1IDH1CYP1A2CYP3A4 | |
| SCHEMBL2299083 | 0.88 | IL6ST (0.47) | IL6STSLC15A1IDH1CYP1A2CYP3A4 | |
| SCHEMBL9739729 | 0.87 | IL6ST (0.59) | IL6STIDH1STAT3CYP1A2NAAA | |
| SCHEMBL9739731 | 0.87 | IL6ST (0.59) | IL6STIDH1STAT3CYP1A2NAAA | |
| SCHEMBL7277673 | 0.87 | IL6ST (0.52) | IL6STIDH1STAT3NAAA | |
| SCHEMBL7274947 | 0.84 | SLC15A1 (0.44) | IL6STSLC15A1AVPR1ACYP1A2CYP3A4 | |
| SCHEMBL7274942 | 0.84 | SLC15A1 (0.44) | IL6STSLC15A1AVPR1ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383635-B1 | Peptides having renin inhibitory activity their preparation and use | SANKYO CO (JP) | 1995-07-12 | — | — | EP | disclosed |
| US-5378689-A | Hypotensive agents; administrable by mouth | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0383635-A2 | Peptides having renin inhibitory activity their preparation and use | Sankyo Company Limited (JP) | 1990-08-22 | — | — | EP | disclosed |