Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TACR1 | P25103 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CPA1 | P15085 | 2/20 | 0.49 |
| ▸ | CPB1 | P15086 | 1/20 | 0.49 |
| ▸ | CPA3 | P15088 | 1/20 | 0.49 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274920 | 0.89 | CPA1 (0.60) | TDP1SMN1; SMN2TACR1KMT2ANPC1 | |
| SCHEMBL6177184 | 0.82 | CYP1A2 (0.69) | LDHAPPARGPPARAKMT2ACPA1 | |
| SCHEMBL12493647 | 0.80 | LDHA (0.65) | LDHAPPARGPPARAKMT2ACPA1 | |
| SCHEMBL7433358 | 0.78 | CPA1 (0.53) | CPA1CPB1CPA3CPB2ANPEP | |
| SCHEMBL6178867 | 0.78 | LDHA (0.67) | ALDH1A1LDHAPPARGPPARAKMT2A | |
| SCHEMBL10436394 | 0.78 | LDHA (0.76) | LDHAPPARGPPARAKMT2A | |
| SCHEMBL16284888 | 0.78 | NPC1 (0.60) | LDHAPPARGPPARAKMT2ANPC1 | |
| SCHEMBL3101828 | 0.78 | NPC1 (0.60) | LDHAPPARGPPARAKMT2ANPC1 | |
| SCHEMBL7442885 | 0.78 | KMT2A (0.77) | TDP1MAPK1SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6672877 | 0.78 | NPC1 (0.60) | LDHAPPARGPPARAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383635-B1 | Peptides having renin inhibitory activity their preparation and use | SANKYO CO (JP) | 1995-07-12 | — | — | EP | disclosed |
| US-5378689-A | Hypotensive agents; administrable by mouth | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0383635-A2 | Peptides having renin inhibitory activity their preparation and use | Sankyo Company Limited (JP) | 1990-08-22 | — | — | EP | disclosed |