Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.85 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.85 |
| ▸ | HTR3B | O95264 | 3/20 | 0.85 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.85 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.85 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29399763 | 0.92 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL4155303 | 0.92 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Maleic Acid SCHEMBL7324754 | 0.86 | HTR3A (0.88) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Fumaric Acid SCHEMBL7324761 | 0.86 | HTR3A (0.88) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8963150 | 0.80 | HTR3A (0.74) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7316274 | 0.79 | HTR3A (0.76) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7286830 | 0.79 | HTR3A (0.72) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Fumaric Acid SCHEMBL7326640 | 0.78 | HTR3A (0.67) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Maleic Acid SCHEMBL7326639 | 0.78 | HTR3A (0.67) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Fumaric Acid SCHEMBL7325601 | 0.77 | HTR3E (0.66) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | disclosed |
| EP-0385722-B1 | Tricyclic lactam derivatives and pharmaceutical compositions containing them | GLAXO GROUP LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| US-5360800-A | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives | GLAXO GROUP LIMITED (GB) | 1994-11-01 | — | — | US | disclosed |
| EP-0306323-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1994-09-21 | — | — | EP | disclosed |
| EP-0345956-B1 | Tricyclic ketones | GLAXO GROUP LTD (GB) | 1994-03-16 | — | — | EP | disclosed |
| EP-0581388-A1 | Pyridoindolone Methansulphonate as 5HT and 5HT3 receptor antagonists | GLAXO GROUP LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |
| EP-0403261-A2 | Amide derivatives | GLAXO GROUP LIMITED (GB) | 1990-12-19 | — | — | EP | disclosed |
| EP-0357415-A2 | Use of serotonin antagonists in the treatment of cognitive disorders | GLAXO GROUP LIMITED (GB) | 1990-03-07 | — | — | EP | disclosed |
| EP-0347229-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |
| EP-0317088-A1 | Ketone derivatives | GLAXO GROUP LIMITED (GB) | 1989-05-24 | — | — | EP | disclosed |