Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.64 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.57 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1849603 | 1.00 | LMNA (0.77) | LMNAKDM4EL3MBTL1PLA2G1BPOLB | |
| SCHEMBL2289990 | 1.00 | LMNA (0.77) | LMNAKDM4EL3MBTL1PLA2G1BPOLB | |
| SCHEMBL6458060 | 0.89 | LMNA (0.64) | LMNAKDM4EL3MBTL1PLA2G1BPOLB | |
| SCHEMBL10133058 | 0.89 | LMNA (0.84) | LMNAKDM4EL3MBTL1PLA2G1BPOLB | |
| SCHEMBL1673479 | 0.88 | LMNA (0.68) | LMNAKDM4EL3MBTL1PLA2G1BPOLB | |
| SCHEMBL14646432 | 0.88 | LMNA (0.68) | LMNAKDM4EL3MBTL1PLA2G1BPOLB | |
| SCHEMBL323956 | 0.88 | LMNA (0.62) | LMNAKDM4EL3MBTL1PLA2G1BPOLB | |
| SCHEMBL2295189 | 0.88 | LMNA (0.62) | LMNAKDM4EL3MBTL1PLA2G1BPOLB | |
| SCHEMBL2296862 | 0.88 | LMNA (0.62) | LMNAKDM4EL3MBTL1PLA2G1BPOLB | |
| SCHEMBL2296260 | 0.88 | LMNA (0.62) | LMNAKDM4EL3MBTL1PLA2G1BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825189-B1 | 1,4-BENZODIOXIN DERIVATIVES | NISSHIN PHARMA INC (JP) | 2002-01-02 | — | — | EP | disclosed |
| US-6130243-A | PROPHYLACTIC OR THERAPEUTIC AGENT FOR DIABETES, HYPERGLYCEMIA AND OBESITY IN MAMMALS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 2000-10-10 | — | — | US | disclosed |
| EP-0825189-A1 | 1,4-BENZODIOXIN DERIVATIVES | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |
| EP-0589446-B1 | N-(Hydroxyethyl)butanediamide derivatives as renin inhibitors | BOEHRINGER INGELHEIM CA LTD (CA) | 1997-09-03 | — | — | EP | disclosed |
| US-5565476-A | RENIN INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND HYPERTENSION | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1996-10-15 | — | — | US | disclosed |
| US-5554634-A | HYPOTENSIVE | BIO-MEGA BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1996-09-10 | — | — | US | disclosed |
| US-5523315-A | N-(hydroxyethyl)butanediamide derivatives | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1996-06-04 | — | — | US | disclosed |
| WO-1994007845-A1 | N-(HYDROXYETHYL)BUTANEDIAMIDE DERIVATIVES AS RENIN INHIBITORS | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1994-04-14 | — | — | WO | disclosed |
| EP-0589446-A1 | N-(Hydroxyethyl)butanediamide derivatives as renin inhibitors | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1994-03-30 | — | — | EP | disclosed |