Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 11/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CPB1 | P15086 | 5/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27803104 | 0.87 | CPB2 (0.51) | CPB2L3MBTL1CPB1CYP2C9CYP2C19 | |
| SCHEMBL27781573 | 0.84 | CPB2 (0.53) | CPB2L3MBTL1CPB1 | |
| SCHEMBL1441194 | 0.82 | CPB2 (0.50) | CPB2L3MBTL1CPB1MAP3K5CYP2E1 | |
| SCHEMBL16831914 | 0.82 | CPB2 (0.45) | CPB2CPB1MAP3K5SMYD3 | |
| SCHEMBL27803097 | 0.82 | CPB2 (0.52) | CPB2CPB1FFAR1 | |
| SCHEMBL27781579 | 0.82 | CPB2 (0.52) | CPB2CPB1FFAR1 | |
| SCHEMBL6369409 | 0.81 | CYP4F2 (0.43) | CPB2L3MBTL1TBXAS1 | |
| SCHEMBL20366150 | 0.80 | CPB2 (0.45) | CPB2CPB1CYP2C9CYP2C19FFAR1 | |
| Oxalic Acid SCHEMBL4079200 | 0.80 | CPB2 (0.56) | CPB2CPB1MAP3K5CYP2E1CYP3A4 | |
| SCHEMBL2629331 | 0.79 | CYP2C9 (0.56) | L3MBTL1CYP2C9CYP2C19NR1H4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545838-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-08-13 | — | — | US | disclosed |
| US-5098924-A | Hypotensive agents and angiotensin II inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0452587-A1 | Dihydroxy sulfonamide and sulfinamide renin inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1991-10-23 | — | — | EP | disclosed |