Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 15/20 | 0.63 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | CDK9 | P50750 | 1/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.58 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13336637 | 0.87 | KDR (0.67) | FYNFGFR3KDR | |
| Hydrochloric Acid SCHEMBL3321535 | 0.86 | KDR (0.66) | FYNFGFR3KDR | |
| SCHEMBL73833 | 0.85 | FGFR3 (0.73) | FGFR3KDR | |
| SCHEMBL3325195 | 0.84 | FGFR3 (0.79) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL3323066 | 0.84 | FYN (0.65) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL23535614 | 0.82 | FYN (0.65) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL30006622 | 0.82 | FYN (0.65) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL13336397 | 0.82 | FYN (0.64) | FYNDYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL3323050 | 0.82 | KDR (0.69) | FYNFGFR3KDR | |
| SCHEMBL3323645 | 0.81 | KDR (0.81) | FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |