Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.65 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15831223 | 0.87 | P4HTM (0.58) | P4HTMGRIA4KMT2AKDM1AALDH1A1 | |
| SCHEMBL18455389 | 0.85 | HDAC1 (0.57) | P4HTMKMT2AALDH1A1SMN1; SMN2CA2 | |
| SCHEMBL21104350 | 0.83 | P4HTM (0.48) | P4HTMGRIA4TP53TSHRNR1H4 | |
| SCHEMBL21104542 | 0.83 | P4HTM (0.55) | P4HTMNR1H4KMT2ACA2CA1 | |
| SCHEMBL20371007 | 0.82 | HDAC1 (0.59) | P4HTMGRIA4NR1H4KMT2ACA2 | |
| SCHEMBL21104541 | 0.81 | FLT1 (0.56) | P4HTMTP53KMT2AALDH1A1CA2 | |
| SCHEMBL21104540 | 0.81 | CA2 (0.62) | P4HTMKMT2ACA2CA1CA12 | |
| SCHEMBL21104351 | 0.81 | P4HTM (0.52) | P4HTMHDAC8 | |
| SCHEMBL9018467 | 0.79 | P4HTM (1.00) | P4HTM | |
| SCHEMBL6091548 | 0.78 | GRIA4 (0.51) | P4HTMGRIA4TP53TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |