Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11235206 | 0.87 | PDE3B (0.38) | PDE3BPDE3AMAPK1KDM4ERAB9A | |
| SCHEMBL11236919 | 0.86 | GSK3B (0.42) | PDE3BPDE3AMAPK1RAB9ANPC1 | |
| SCHEMBL11236724 | 0.84 | GSK3B (0.38) | PDE3BPDE3AMAPK1KDM4ERAB9A | |
| SCHEMBL11233222 | 0.83 | GSK3B (0.40) | PDE3BPDE3AMAPK1RAB9ANPC1 | |
| SCHEMBL11245356 | 0.81 | CYP2A6 (0.44) | MAPK1HSD17B10GRM2ALDH1A1 | |
| SCHEMBL7273135 | 0.81 | MTOR (0.42) | AAK1 | |
| SCHEMBL11104033 | 0.80 | PDE3B (0.44) | PDE3BPDE3AKDM4EHSD17B10RAB9A | |
| SCHEMBL11242084 | 0.80 | PDE3B (0.47) | PDE3BPDE3AMAPK1KDM4EHSD17B10 | |
| SCHEMBL11236432 | 0.80 | PDE3B (0.51) | PDE3BPDE3AMAPK1KDM4EHSD17B10 | |
| SCHEMBL11246333 | 0.78 | PDE3B (0.45) | PDE3BPDE3ARAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4463008-A | 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof | STERLING DRUG INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0109027-A1 | Pyridine derivatives, process for their preparation and composition containing them | STERLING DRUG INC. (US) | 1984-05-23 | — | — | EP | disclosed |
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |