Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GLP1R | P43220 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HEXA | P06865 | 1/20 | 0.33 |
| ▸ | HEXB | P07686 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236919 | 0.92 | GSK3B (0.42) | PDE3BPDE3AGRM2MAPK1GSK3B | |
| SCHEMBL11236724 | 0.91 | GSK3B (0.38) | PDE3BPDE3AGRM2MAPK1GSK3B | |
| SCHEMBL7278975 | 0.87 | PDE3B (0.49) | PDE3BPDE3AGRM2MAPK1GSK3B | |
| SCHEMBL11241603 | 0.81 | PDE3B (0.53) | PDE3BPDE3AMAPK1KDM4EALDH1A1 | |
| SCHEMBL11233222 | 0.80 | GSK3B (0.40) | PDE3BPDE3AMAPK1GSK3BRAB9A | |
| SCHEMBL11224797 | 0.79 | RAB9A (0.41) | PDE3BPDE3ARAB9ANPC1ALDH1A1 | |
| SCHEMBL11165295 | 0.79 | CASP1 (0.49) | CASP1MAPT | |
| SCHEMBL11248447 | 0.78 | SMN1; SMN2 (0.40) | PDE3BPDE3AMAPK1GSK3BRAB9A | |
| SCHEMBL7279946 | 0.78 | PDE3B (0.36) | PDE3BPDE3AGRM2MAPK1GSK3B | |
| SCHEMBL11377753 | 0.77 | CYP46A1 (0.49) | PDE3BPDE3AMAPK1GSK3BCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |