Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.48 |
| ▸ | HRH1 | P35367 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365630 | 0.89 | TDP1 (0.50) | TDP1ALOX5HRH1 | |
| SCHEMBL10365243 | 0.88 | HRH1 (0.58) | TDP1ALOX5HRH1 | |
| SCHEMBL7289453 | 0.88 | TDP1 (0.64) | TDP1ALOX5HRH1MEN1KMT2A | |
| SCHEMBL10365491 | 0.87 | DRD3 (0.51) | TDP1HRH1MEN1KMT2A | |
| SCHEMBL10364801 | 0.84 | TDP1 (0.59) | TDP1HRH1MEN1KMT2A | |
| SCHEMBL10365454 | 0.81 | LMNA (0.53) | HRH1MEN1KMT2A | |
| SCHEMBL10366021 | 0.81 | TDP1 (0.58) | TDP1ALOX5HRH1 | |
| SCHEMBL22882677 | 0.77 | MGAM (0.43) | MEN1KMT2A | |
| Efletirizine SCHEMBL18816 | 0.77 | HRH1 (0.72) | ACHETDP1HRH1MEN1KMT2A | |
| Efletirizine SCHEMBL8211713 | 0.76 | HRH1 (0.71) | ACHETDP1HRH1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0094159-B1 | DIHYDROPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-03-14 | — | — | EP | disclosed |
| US-4892875-A | HYPOTENSIVE, RENAL VASODILATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| US-4603135-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-29 | — | — | US | disclosed |
| EP-0138505-A2 | Dihydropyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-04-24 | — | — | EP | disclosed |
| EP-0094159-A1 | Dihydropyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-11-16 | — | — | EP | disclosed |