Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 19/20 | 0.47 |
| ▸ | TMPRSS15 | P98073 | 19/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7276917 | 0.94 | PRSS1 (0.49) | PRSS1TMPRSS15 | |
| SCHEMBL7276273 | 0.90 | PRSS1 (0.54) | PRSS1TMPRSS15FTO | |
| SCHEMBL7279367 | 0.85 | PRSS1 (0.55) | PRSS1TMPRSS15FTO | |
| Hydrochloric Acid SCHEMBL7286807 | 0.85 | PRSS1 (0.57) | PRSS1TMPRSS15 | |
| SCHEMBL7279019 | 0.84 | PRSS1 (0.53) | PRSS1TMPRSS15FTO | |
| SCHEMBL10855686 | 0.83 | PRSS1 (0.56) | PRSS1TMPRSS15FTO | |
| SCHEMBL7286071 | 0.80 | PRSS1 (0.49) | PRSS1TMPRSS15FTO | |
| Hydrochloric Acid SCHEMBL7284772 | 0.80 | PRSS1 (0.59) | PRSS1TMPRSS15 | |
| Bromide SCHEMBL7276348 | 0.80 | PRSS1 (0.59) | PRSS1TMPRSS15 | |
| SCHEMBL7279068 | 0.80 | PRSS1 (0.50) | PRSS1TMPRSS15FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532267-A | Amidinonaphthyl furancarboxylate derivatives and acid addition salts therof | TORII & CO., LTD. (JP) | 1996-07-02 | — | — | US | claimed |
| US-5532267-A | Amidinonaphthyl furancarboxylate derivatives and acid addition salts therof | TORII & CO., LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0556024-B1 | Novel amidinonaphthyl furancarboxylate derivatives and acid addition salts thereof | TORII & CO LTD (JP) | 1995-08-02 | — | — | EP | disclosed |
| EP-0556024-A1 | Novel amidinonaphthyl furancarboxylate derivatives and acid addition salts thereof | TORII & CO., LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |