Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.47 |
| ▸ | HTR3B | O95264 | 4/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pumosetrag SCHEMBL1497800 | 0.88 | HTR3A (0.56) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Pumosetrag SCHEMBL1497797 | 0.88 | HTR3A (0.56) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Pumosetrag SCHEMBL7287985 | 0.88 | HTR3A (0.56) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Pumosetrag SCHEMBL9432501 | 0.87 | HTR3A (0.55) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Pumosetrag SCHEMBL9432490 | 0.87 | HTR3A (0.55) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7334303 | 0.73 | CYP3A4 (0.34) | HTR3ACYP3A4 | |
| SCHEMBL7279446 | 0.73 | HTR3E (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7284925 | 0.71 | MEN1 (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7441918 | 0.69 | HTR3E (0.53) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9059703 | 0.69 | CHRNA7 (0.53) | HTR3ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560348-B1 | Thieno 3,2-b pyridine derivatives for the treatment of gastrointestinal disorders | MITSUBISHI CHEM CORP (JP) | 2002-07-10 | — | — | EP | disclosed |
| US-5352685-A | Gastrointestinal disorders | MITSUBISHI KASEI CORPORATION (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0560348-A1 | Thieno 3,2-b pyridine derivatives for the treatment of gastrointestinal disorders | Mitsubishi Chemical Corporation (JP) | 1993-09-15 | — | — | EP | disclosed |