Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15778320 | 0.81 | KMT2A (0.36) | HPGDKMT2AMEN1MAPTATM | |
| SCHEMBL9822530 | 0.78 | EPHX1 (0.50) | HPGDKMT2AMEN1MAPTATM | |
| SCHEMBL15355129 | 0.78 | MEN1 (0.50) | HPGDKMT2AMEN1MAPTATM | |
| SCHEMBL6799750 | 0.77 | EPHX1 (0.63) | KMT2AMEN1EPHX1CTSSCTSK | |
| SCHEMBL13561009 | 0.76 | CTSK (0.41) | KMT2AEPHX1CTSSCTSKGAA | |
| SCHEMBL8349429 | 0.75 | MEN1 (0.48) | HPGDKMT2AMEN1MAPTATM | |
| SCHEMBL60318 | 0.75 | EPHX1 (0.56) | KMT2AEPHX1CTSSCTSKGAA | |
| SCHEMBL4073139 | 0.74 | EPHX1 (0.60) | KMT2AMEN1EPHX1CTSSCTSK | |
| SCHEMBL18177843 | 0.74 | HPGD (0.59) | HPGDKMT2AMEN1MAPTATM | |
| SCHEMBL16772732 | 0.74 | GAA (0.50) | HPGDKMT2AMEN1MAPTEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098924-A | Hypotensive agents and angiotensin II inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0452587-A1 | Dihydroxy sulfonamide and sulfinamide renin inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1991-10-23 | — | — | EP | disclosed |