Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.48 |
| ▸ | CLK1 | P49759 | 3/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | CLK3 | P49761 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272491 | 0.92 | DYRK1A (0.47) | DYRK1ACLK1CLK2CLK3CDK5 | |
| SCHEMBL11065116 | 0.78 | GABRP (0.42) | CYP3A4CYP2D6PDE3APDE3BMAPK1 | |
| SCHEMBL7279946 | 0.78 | PDE3B (0.36) | MAPK13MAPK12MAPK11MAPK14CYP3A4 | |
| SCHEMBL7278594 | 0.75 | DYRK1A (0.54) | DYRK1ACLK1CLK2CLK3CDK5 | |
| SCHEMBL7271215 | 0.73 | CYP19A1 (0.45) | DYRK1ACLK1CLK2CLK3CDK5 | |
| SCHEMBL22375607 | 0.73 | PDE10A (0.43) | PDE10APDE3APDE2APDE5APDE4A | |
| SCHEMBL10264276 | 0.71 | PDE10A (0.39) | PDE10APDE3APDE2APDE5APDE4A | |
| SCHEMBL11164012 | 0.70 | GABRP (0.51) | CLK4CYP3A4CYP2D6PDE3APDE3B | |
| SCHEMBL7280225 | 0.70 | MAPT (0.40) | CYP3A4CYP2D6PDE3APDE3BMAPK1 | |
| SCHEMBL27662863 | 0.70 | RAF1 (0.40) | DYRK1ARAF1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4463008-A | 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof | STERLING DRUG INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0109027-A1 | Pyridine derivatives, process for their preparation and composition containing them | STERLING DRUG INC. (US) | 1984-05-23 | — | — | EP | disclosed |