Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CLK3 | P49761 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279983 | 0.92 | DYRK1A (0.48) | DYRK1ACLK1CLK2CLK3CDK5 | |
| SCHEMBL11164012 | 0.78 | GABRP (0.51) | CLK4CYP3A4CYP2D6NPC1ALDH1A1 | |
| SCHEMBL7280225 | 0.78 | MAPT (0.40) | CYP3A4CYP2D6NPC1ALDH1A1MAPT | |
| SCHEMBL11247740 | 0.75 | CYP3A4 (0.37) | CLK4CYP3A4CYP2D6NPC1ALDH1A1 | |
| SCHEMBL11176428 | 0.74 | CYP3A4 (0.39) | CYP3A4CYP2D6NPC1ALDH1A1MAPT | |
| SCHEMBL11074069 | 0.74 | GABRP (0.47) | CLK4CYP3A4CYP2D6NPC1ALDH1A1 | |
| SCHEMBL7278594 | 0.74 | DYRK1A (0.54) | DYRK1ACLK1CLK2CLK3CDK5 | |
| SCHEMBL7271215 | 0.72 | CYP19A1 (0.45) | DYRK1ACLK1CLK2CLK3CDK5 | |
| SCHEMBL26612262 | 0.71 | PDE10A (0.44) | PDE10A | |
| SCHEMBL31414676 | 0.71 | PDE10A (0.44) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4463008-A | 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof | STERLING DRUG INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0109027-A1 | Pyridine derivatives, process for their preparation and composition containing them | STERLING DRUG INC. (US) | 1984-05-23 | — | — | EP | disclosed |