Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | CCKBR | P32239 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10855298 | 0.91 | POLB (0.47) | POLBMAPTLMNAHTTKMT2A | |
| SCHEMBL7288638 | 0.89 | PDPK1 (0.44) | POLBLMNAHTTPDPK1CCKBR | |
| SCHEMBL9830525 | 0.82 | RAB9A (0.49) | POLBMAPTLMNAKDM4ERAB9A | |
| SCHEMBL7301823 | 0.81 | POLB (0.40) | POLBMAPTLMNAHTTKMT2A | |
| SCHEMBL7291385 | 0.80 | CYP3A4 (0.40) | POLBMAPTLMNAHTTKMT2A | |
| SCHEMBL7302763 | 0.79 | CYP3A4 (0.44) | POLBLMNAHTTKMT2AMEN1 | |
| SCHEMBL7288807 | 0.79 | POLB (0.42) | POLBMAPTLMNAHTTKMT2A | |
| SCHEMBL10509805 | 0.76 | ACE (0.47) | LMNAKMT2AMEN1GSK3BTSHR | |
| SCHEMBL10508518 | 0.76 | ACE (0.43) | CCKBRTP53TSHR | |
| SCHEMBL10510913 | 0.76 | ACE (0.45) | PDPK1GSK3BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4584300-A | Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1986-04-22 | — | — | US | disclosed |
| EP-0116368-A1 | Benzothiazine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-22 | — | — | EP | disclosed |