Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302763 | 0.90 | CYP3A4 (0.44) | POLBCYP3A4LMNAHTTMEN1 | |
| SCHEMBL7288807 | 0.85 | POLB (0.42) | POLBMAPTLMNAHTTMEN1 | |
| SCHEMBL7291385 | 0.84 | CYP3A4 (0.40) | POLBCYP3A4MAPTLMNAHTT | |
| SCHEMBL7280075 | 0.81 | POLB (0.46) | POLBCYP3A4MAPTLMNAHTT | |
| SCHEMBL10855298 | 0.80 | POLB (0.47) | POLBMAPTLMNAHTTMEN1 | |
| SCHEMBL7298983 | 0.78 | HDAC3 (0.41) | POLBCYP3A4LMNAHTTGSK3B | |
| SCHEMBL7278961 | 0.78 | CACNA1S (0.52) | CYP3A4MAPTLMNAHTTMEN1 | |
| SCHEMBL7292897 | 0.77 | CACNA1S (0.53) | CYP3A4MAPTLMNAHTTMEN1 | |
| SCHEMBL9748247 | 0.76 | RAB9A (0.40) | POLBCYP3A4MAPTLMNACACNA1S | |
| SCHEMBL4347254 | 0.76 | CYP3A4 (0.54) | POLBCYP3A4MAPTALDH1A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4584300-A | Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1986-04-22 | — | — | US | disclosed |
| EP-0116368-A1 | Benzothiazine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-22 | — | — | EP | disclosed |