Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15710798 | 0.73 | — | — | |
| SCHEMBL17397278 | 0.71 | NPC1 (0.36) | NPC1MAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL15710868 | 0.70 | — | — | |
| SCHEMBL4125262 | 0.68 | TSHR (0.40) | NPC1MAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL4784913 | 0.68 | — | — | |
| SCHEMBL4125267 | 0.68 | TSHR (0.40) | NPC1MAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL15349970 | 0.67 | KMT2A (0.57) | NPC1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL15349961 | 0.67 | KMT2A (0.57) | NPC1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL27677607 | 0.67 | — | — | |
| SCHEMBL319864 | 0.66 | ALDH1A1 (0.41) | NPC1MAPTLMNAUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001633-A1 | Processes for preparing tri-heterocyclic substituted methanes and their conversion into further intermediates useful in the preparation of pharmacologically active compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-05-02 | — | — | EP | disclosed |