Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.31 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6454724 | 0.84 | RECQL (0.49) | NPC1MAPTUSP2ALDH1A1LMNA | |
| SCHEMBL28094529 | 0.73 | ALDH1A1 (0.39) | NPC1MAPTUSP2ALDH1A1LMNA | |
| SCHEMBL18195434 | 0.73 | ALDH1A1 (0.39) | NPC1MAPTUSP2ALDH1A1LMNA | |
| SCHEMBL6772333 | 0.73 | NFE2L2 (0.52) | NPC1MAPTUSP2ALDH1A1LMNA | |
| SCHEMBL6772335 | 0.73 | NFE2L2 (0.52) | NPC1MAPTUSP2ALDH1A1LMNA | |
| SCHEMBL15601151 | 0.72 | CHRNB2 (0.42) | MAPTALDH1A1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL11299053 | 0.71 | ALDH1A1 (0.41) | NPC1MAPTUSP2ALDH1A1LMNA | |
| SCHEMBL16807838 | 0.71 | ALDH1A1 (0.41) | NPC1MAPTUSP2ALDH1A1LMNA | |
| SCHEMBL1144907 | 0.71 | NFE2L2 (0.50) | NPC1MAPTUSP2ALDH1A1LMNA | |
| SCHEMBL1144905 | 0.71 | NFE2L2 (0.50) | NPC1MAPTUSP2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | claimed |
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | disclosed |