Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 17/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272612 | 0.93 | REN (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7287334 | 0.93 | KLK7 (0.41) | RENKLK7 | |
| SCHEMBL7274295 | 0.89 | KLK7 (0.42) | RENKLK7 | |
| SCHEMBL7279531 | 0.89 | REN (0.41) | RENKLK7 | |
| SCHEMBL7285856 | 0.89 | KLK7 (0.39) | RENKLK7 | |
| SCHEMBL7271684 | 0.88 | REN (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9358842 | 0.84 | KLK7 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9011568 | 0.80 | REN (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9355061 | 0.79 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7273810 | 0.78 | KLK7 (0.42) | RENKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| EP-0476515-A1 | New amino acid derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |