Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 10/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 8/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611242 | 0.87 | GBA1 (0.62) | GBA1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL14727594 | 0.85 | GBA1 (0.59) | GBA1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7286156 | 0.82 | CYP1A2 (0.58) | GBA1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL16183747 | 0.81 | CYP1A2 (0.61) | GBA1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL17212398 | 0.80 | GBA1 (0.61) | GBA1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL20273688 | 0.79 | GBA1 (0.60) | GBA1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL14727599 | 0.78 | PDE5A (0.57) | GBA1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL14727595 | 0.78 | CYP1A2 (0.55) | GBA1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7059580 | 0.78 | CYP1A2 (0.43) | ALDH1A1LMNACYP1A2CYP3A4MEN1 | |
| SCHEMBL7607012 | 0.78 | GBA1 (0.57) | GBA1ALDH1A1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | claimed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | claimed |