Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.34 |
| ▸ | GHSR | Q92847 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5996258 | 0.82 | SLC6A2 (0.45) | ADRA2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL5995989 | 0.81 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3KCNH2LMNA | |
| SCHEMBL5993827 | 0.76 | TDP1 (0.32) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL6945379 | 0.75 | LTA4H (0.38) | LTA4HSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL5995472 | 0.75 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL5996081 | 0.74 | CHRNB2 (0.34) | — | |
| SCHEMBL5965220 | 0.73 | NPC1 (0.38) | — | |
| SCHEMBL4338880 | 0.73 | NPC1 (0.38) | — | |
| SCHEMBL7699878 | 0.70 | CYP1A2 (0.51) | GHSRTSHR | |
| SCHEMBL20142303 | 0.70 | GBA1 (0.46) | SLC6A2SLC6A4SLC6A3TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |