Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.62 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.62 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.62 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.62 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 7/20 | 0.44 |
| ▸ | REN | P00797 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PEPD | P12955 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596841 | 0.98 | DPP4 (0.63) | DPP4DPP8DPP9DPP7ERAP2 | |
| SCHEMBL4409965 | 0.98 | DPP4 (0.63) | DPP4DPP8DPP9DPP7ERAP2 | |
| SCHEMBL4411036 | 0.98 | DPP4 (0.63) | DPP4DPP8DPP9DPP7ERAP2 | |
| Hydrochloric Acid SCHEMBL11331994 | 0.97 | DPP4 (0.62) | DPP4DPP8DPP9DPP7ERAP2 | |
| Hydrochloric Acid SCHEMBL11168287 | 0.93 | DPP4 (0.57) | DPP4DPP8DPP9DPP7ERAP2 | |
| Trifluoroacetic Acid SCHEMBL9508365 | 0.90 | DPP4 (0.54) | DPP4DPP8DPP9DPP7ERAP2 | |
| SCHEMBL30729290 | 0.87 | DPP4 (0.63) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL3052901 | 0.87 | DPP4 (0.63) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL10056816 | 0.87 | DPP4 (0.63) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL30567640 | 0.87 | DPP4 (0.63) | DPP4DPP8DPP9DPP7ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0473993-B1 | Novel peptide derivatives and their pharmaceutical use | JAPAN TOBACCO INC (JP) | 1996-04-17 | — | — | EP | disclosed |
| US-5151497-A | Central nervous system disorders, antidepressants, epilepsy and cognition activators | JAPAN TOBACCO INC. (JP) | 1992-09-29 | — | — | US | disclosed |
| EP-0473993-A2 | Novel peptide derivatives and their pharmaceutical use | Japan Tobacco Inc. (JP) | 1992-03-11 | — | — | EP | disclosed |