Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.60 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.60 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.60 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278495 | 0.89 | PLAAT3 (0.74) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23417617 | 0.88 | ALDH1A1 (0.77) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL17117415 | 0.87 | PLAAT3 (0.74) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10436226 | 0.86 | PLAAT3 (0.73) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4026595 | 0.86 | PLAAT3 (0.80) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11282670 | 0.86 | ERCC1 (0.65) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7274811 | 0.86 | ALDH1A1 (0.70) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23392535 | 0.85 | MAPT (0.77) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11371390 | 0.85 | ERCC1 (0.64) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27407288 | 0.83 | EPHX2 (0.74) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375668-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1990-06-27 | — | — | EP | disclosed |
| US-4885313-A | 3,4-Dihydroxyphenylethylamine derivatives and their use | FISONS PLC (GB) | 1989-12-05 | — | — | US | disclosed |
| US-4803225-A | Dihydroxy-phenethylamino compounds useful as pharmaceuticals | FISONS, PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| US-4720586-A | Substituted 3,4-dihydroxy-phenylethylamino compounds | FISONS, PLC (GB) | 1988-01-19 | — | — | US | disclosed |
| EP-0142283-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1985-05-22 | — | — | EP | disclosed |