Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13406018 | 0.83 | PDE2A (0.52) | KDM4ECYP1A2CYP3A4PDE2AAMY1A | |
| SCHEMBL7270959 | 0.78 | PDE2A (0.58) | KDM4ECYP1A2CYP3A4PDE2AAMY1A | |
| SCHEMBL11237399 | 0.77 | PDE2A (0.51) | KDM4ECYP1A2CYP3A4PDE2AAMY1A | |
| Hydrochloric Acid SCHEMBL7272531 | 0.77 | PDE2A (0.57) | KDM4ECYP1A2CYP3A4PDE2AAMY1A | |
| SCHEMBL10734755 | 0.75 | PDE2A (0.57) | KDM4ECYP1A2CYP3A4PDE2AAMY1A | |
| SCHEMBL7280668 | 0.74 | PDE2A (0.57) | KDM4ECYP1A2CYP3A4PDE2AAMY1A | |
| SCHEMBL12470674 | 0.74 | PDE2A (0.56) | KDM4ECYP1A2CYP3A4PDE2AAMY1A | |
| SCHEMBL3337825 | 0.73 | PDE2A (0.66) | KDM4EPDE2AAMY1AHTTSMN1; SMN2 | |
| SCHEMBL10690574 | 0.72 | PDE2A (0.51) | KDM4ECYP1A2CYP3A4PDE2AAMY1A | |
| SCHEMBL7272145 | 0.71 | PDE2A (0.56) | KDM4ECYP1A2CYP3A4PDE2AAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904785-A | INOTROPIC AGENTS FOR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4758574-A | 2-phenylimidazio (4,5-c) pyridines | ELI LILLY AND COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| US-4603139-A | 2-PHENYL-1H-IMIDAZOL(4,5-C)PYRIDINES, ANTICXOAGULANTS, CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. | 1986-07-29 | — | — | US | disclosed |
| EP-0093593-A2 | Pyridine compounds | ELI LILLY AND COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |
| EP-0079083-A1 | New imidazo[4,5-c]pyridine derivatives, processes for their preparation and pharmaceutical formulations containing such compounds | MERCK PATENT GmbH (DE) | 1983-05-18 | — | — | EP | disclosed |