Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.56 |
| ▸ | THRA | P10827 | 5/20 | 0.56 |
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19114016 | 0.93 | THRB (0.60) | THRBTHRASLC7A5MEN1KMT2A | |
| SCHEMBL3291891 | 0.91 | THRB (0.58) | THRBTHRASLC7A5MEN1KMT2A | |
| SCHEMBL3290593 | 0.91 | THRB (0.58) | THRBTHRASLC7A5MEN1KMT2A | |
| SCHEMBL19113872 | 0.84 | THRB (0.55) | THRBTHRASLC7A5MEN1KMT2A | |
| SCHEMBL2674668 | 0.83 | SLC7A5 (0.52) | THRBTHRASLC7A5MEN1KMT2A | |
| SCHEMBL29510634 | 0.83 | SLC7A5 (0.58) | THRBTHRASLC7A5MEN1KMT2A | |
| SCHEMBL2674665 | 0.83 | SLC7A5 (0.52) | THRBTHRASLC7A5MEN1KMT2A | |
| SCHEMBL2931777 | 0.83 | SLC7A5 (0.52) | THRBTHRASLC7A5MEN1KMT2A | |
| SCHEMBL2674679 | 0.83 | SLC7A5 (0.52) | THRBTHRASLC7A5MEN1KMT2A | |
| SCHEMBL5323478 | 0.82 | SLC7A5 (0.58) | THRBTHRASLC7A5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766110-A | INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS | RYAN JAMES W (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0073143-B1 | NOVEL COMPLEX AMIDO AND IMIDO DERIVATIVES OF CARBOXYALKYL PEPTIDES AND THIOETHERS AND ETHERS OF PEPTIDES | Ryan, James Walter (US) | 1985-11-21 | — | — | EP | disclosed |
| EP-0048159-A2 | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents | UNIVERSITY OF MIAMI (US) | 1982-03-24 | — | — | EP | disclosed |