Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7292267 | 0.86 | SMPD1 (0.47) | ALDH1A1CTSKHDAC1MAPTKMT2A | |
| SCHEMBL1968491 | 0.84 | KMT2A (0.55) | ALDH1A1MAPTKMT2APLA2G4BPTPN1 | |
| SCHEMBL8361241 | 0.84 | HDAC1 (0.53) | ALDH1A1HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL8770370 | 0.84 | TP53 (0.68) | ALDH1A1MAPTKMT2APOLBTP53 | |
| SCHEMBL864308 | 0.83 | HDAC1 (0.61) | ALDH1A1CTSKHDAC1HDAC3HDAC2 | |
| SCHEMBL12697639 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTKMT2APOLBTP53 | |
| SCHEMBL7289218 | 0.79 | HDAC1 (0.56) | ALDH1A1HDAC1HDAC3HDAC2MAPT | |
| SCHEMBL24899403 | 0.78 | ITGB3 (0.59) | ALDH1A1KMT2ACASP1MEN1 | |
| SCHEMBL8336016 | 0.78 | ITGB3 (0.59) | ALDH1A1CTSKKMT2ACASP1MEN1 | |
| SCHEMBL29115912 | 0.78 | ITGB3 (0.67) | PTPN1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981531-A | FOR INHIBITING PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1999-11-09 | — | — | US | disclosed |
| US-5760057-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1998-06-02 | — | — | US | disclosed |
| EP-0632016-B1 | 1,2-Diacylated hydrazine derivatives and their use as cell adhesion inhibitors | ZENECA LTD (GB) | 1997-04-09 | — | — | EP | disclosed |
| US-5612373-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1997-03-18 | — | — | US | disclosed |
| WO-1995000472-A1 | 1,2 DIACYLATED HYDRAZINE DERIVATIVES AND THEIR USE AS ALL ADHESION INHIBITORS | ZENECA LIMITED (GB) | 1995-01-05 | — | — | WO | disclosed |
| EP-0632016-A1 | 1,2-Diacylated hydrazine derivatives and their use as cell adhesion inhibitors | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |