Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280680 | 1.00 | LMNA (0.43) | LMNAPDK2PTGER2PSEN1PSEN2 | |
| SCHEMBL5234625 | 0.82 | LMNA (0.43) | LMNAPTGER2PSEN1PSEN2APH1B | |
| SCHEMBL5233981 | 0.82 | LMNA (0.43) | LMNAPTGER2PSEN1PSEN2APH1B | |
| SCHEMBL5233974 | 0.82 | LMNA (0.43) | LMNAPTGER2PSEN1PSEN2APH1B | |
| SCHEMBL27939222 | 0.81 | HCRTR1 (0.44) | LMNAPTGER2 | |
| SCHEMBL27939223 | 0.81 | HCRTR1 (0.44) | LMNAPTGER2 | |
| SCHEMBL19575250 | 0.81 | BCHE (0.44) | LMNAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6879875 | 0.80 | SRD5A1 (0.42) | — | |
| SCHEMBL4193681 | 0.79 | LMNA (0.43) | LMNACTSLCTSBCTSKTSHR | |
| SCHEMBL4193675 | 0.79 | LMNA (0.43) | LMNACTSLCTSBCTSKTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006511-A | Treating hypertension, congestive heart failure | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0312283-A2 | Di-or tripeptide renin inhibitors containing lactam conformational restrictions in ACHPA | MERCK & CO. INC. (US) | 1989-04-19 | — | — | EP | disclosed |