Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.38 |
| ▸ | REN | P00797 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284822 | 0.90 | ITGB3 (0.42) | ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL7275265 | 0.86 | ITGB3 (0.39) | ITGB3ITGA2BRENCYP3A4NPC1 | |
| Hydrochloric Acid SCHEMBL7282706 | 0.85 | ITGB3 (0.39) | ITGB3ITGA2BRENCYP3A4NPC1 | |
| Hydrochloric Acid SCHEMBL7272656 | 0.84 | ITGB3 (0.38) | ITGB3ITGA2BRENCYP3A4TMPRSS2 | |
| Hydrochloric Acid SCHEMBL9432816 | 0.84 | ITGB3 (0.38) | ITGB3ITGA2BRENCYP3A4SCN9A | |
| SCHEMBL7274019 | 0.84 | REN (0.38) | ITGB3ITGA2BRENCYP3A4TMPRSS2 | |
| Hydrochloric Acid SCHEMBL7273545 | 0.83 | MAPT (0.41) | ITGB3ITGA2BNPC1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL7273115 | 0.83 | REN (0.38) | ITGB3ITGA2BRENCYP3A4TMPRSS2 | |
| Hydrochloric Acid SCHEMBL7281082 | 0.82 | REN (0.37) | ITGB3ITGA2BRENCYP3A4NPC1 | |
| Hydrochloric Acid SCHEMBL7282101 | 0.82 | ITGB3 (0.37) | ITGB3ITGA2BRENCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |