Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.77 |
| ▸ | DRD1 | P21728 | 4/20 | 0.77 |
| ▸ | DRD3 | P35462 | 4/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.77 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.77 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.77 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.77 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.77 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.77 |
| ▸ | HRH1 | P35367 | 1/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | IGF1R | P08069 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10535905 | 0.98 | ADRB2 (0.75) | ADRB2DRD1DRD3ADORA3ADRA2B | |
| SCHEMBL10908415 | 0.93 | ADRB2 (0.87) | ADRB2DRD1DRD3ADORA3ADRA2B | |
| SCHEMBL7272207 | 0.89 | ADRB2 (0.97) | ADRB2DRD1DRD3ADORA3ADRA2B | |
| Bromide SCHEMBL7272394 | 0.87 | ADRB2 (0.94) | ADRB2DRD1DRD3ADORA3ADRA2B | |
| SCHEMBL7278498 | 0.87 | ADRB2 (1.00) | ADRB2DRD1DRD3ADORA3ADRA2B | |
| Dopexamine SCHEMBL122233 | 0.87 | ADRB2 (1.00) | ADRB2DRD1DRD3ADORA3ADRA2B | |
| Dopexamine SCHEMBL5605569 | 0.87 | ADRB2 (1.00) | ADRB2DRD1DRD3ADORA3ADRA2B | |
| Dopexamine SCHEMBL29711811 | 0.87 | ADRB2 (1.00) | ADRB2DRD1DRD3ADORA3ADRA2B | |
| SCHEMBL7272201 | 0.87 | ADRB2 (1.00) | ADRB2DRD1DRD3ADORA3ADRA2B | |
| Bromide SCHEMBL7273851 | 0.86 | ADRB2 (0.71) | ADRB2DRD1DRD3ADORA3ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375668-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1990-06-27 | — | — | EP | claimed |
| US-4720586-A | Substituted 3,4-dihydroxy-phenylethylamino compounds | FISONS, PLC (GB) | 1988-01-19 | — | — | US | claimed |
| EP-0142283-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1985-05-22 | — | — | EP | claimed |
| EP-0375668-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1990-06-27 | — | — | EP | disclosed |
| US-4803225-A | Dihydroxy-phenethylamino compounds useful as pharmaceuticals | FISONS, PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| US-4720586-A | Substituted 3,4-dihydroxy-phenylethylamino compounds | FISONS, PLC (GB) | 1988-01-19 | — | — | US | disclosed |
| EP-0142283-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1985-05-22 | — | — | EP | disclosed |