Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 6/20 | 0.34 |
| ▸ | F2 | P00734 | 5/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275727 | 0.91 | ITGB3 (0.37) | ITGB3ITGA2BHDAC1OPRM1OPRK1 | |
| SCHEMBL7281403 | 0.91 | ITGB3 (0.39) | ITGB3ITGA2BF10F2PRSS1 | |
| SCHEMBL7274583 | 0.90 | ITGB3 (0.40) | ITGB3ITGA2BHDAC1F10F2 | |
| SCHEMBL8573568 | 0.88 | ITGB3 (0.38) | ITGB3ITGA2BHDAC1OPRM1OPRK1 | |
| SCHEMBL7281448 | 0.88 | SRD5A1 (0.41) | ITGB3ITGA2BHDAC1F10F2 | |
| SCHEMBL7285027 | 0.85 | ITGB3 (0.42) | ITGB3ITGA2BF10F2PRSS1 | |
| SCHEMBL7283803 | 0.83 | ITGB3 (0.36) | ITGB3ITGA2BHDAC1F10F2 | |
| SCHEMBL7276094 | 0.82 | ITGB3 (0.47) | ITGB3ITGA2BF10F2PRSS1 | |
| SCHEMBL7280958 | 0.80 | HDAC1 (0.40) | ITGB3ITGA2BPLA2G1BATG4BHDAC1 | |
| SCHEMBL7281659 | 0.79 | ALDH1A1 (0.39) | ITGB3ITGA2BF10F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |