Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SDCBP | O00560 | 1/20 | 0.46 |
| ▸ | SDC2 | P34741 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280949 | 1.00 | ALDH1A1 (0.57) | ALDH1A1GAAPOLBL3MBTL1KMT2A | |
| SCHEMBL7280961 | 1.00 | ALDH1A1 (0.57) | ALDH1A1GAAPOLBL3MBTL1KMT2A | |
| SCHEMBL7272829 | 0.94 | ALDH1A1 (0.55) | ALDH1A1GAAPOLBL3MBTL1KMT2A | |
| SCHEMBL9084021 | 0.86 | ALDH1A1 (0.56) | ALDH1A1GAAPOLBL3MBTL1KMT2A | |
| SCHEMBL9084034 | 0.86 | ALDH1A1 (0.56) | ALDH1A1GAAPOLBL3MBTL1KMT2A | |
| SCHEMBL7281721 | 0.84 | ALDH1A1 (0.54) | ALDH1A1GAAPOLBL3MBTL1KMT2A | |
| SCHEMBL7274235 | 0.83 | ALDH1A1 (0.66) | ALDH1A1GAAPOLBL3MBTL1KMT2A | |
| SCHEMBL7281365 | 0.83 | ALDH1A1 (0.59) | ALDH1A1GAAPOLBL3MBTL1KMT2A | |
| SCHEMBL7281335 | 0.83 | ALDH1A1 (0.59) | ALDH1A1GAAPOLBL3MBTL1KMT2A | |
| SCHEMBL7281322 | 0.83 | ALDH1A1 (0.59) | ALDH1A1GAAPOLBL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481522-B1 | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1997-12-29 | — | — | EP | disclosed |
| EP-0534363-B1 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5591739-A | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0534492-B1 | Carboxyalkyl substituted inhibitors of enkephalinase and ACE | MERRELL PHARMA INC (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0534396-B1 | 2-Substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5529997-A | ADMINISTERING FOR ANALGESIC, HYPOTENSIVE OR DIURETIC EFFECT OR TO TREAT CONGESTIVE HEART FAILURE OR IRRITABLE BOWEL SYNDROME | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-25 | — | — | US | disclosed |
| US-5529996-A | USEFUL FOR CONGESTIVE HEART FAILURE, DIURETIC EFFECT, IRRITABLE BOWL MOVEMENT, ENDORPHIN OR ENKEPHALIN MEDIATED ANALGESIC EFFECTS AND ALSO HYPOTENSIVE AGENT | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-25 | — | — | US | disclosed |
| US-5527795-A | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-18 | — | — | US | disclosed |
| US-5491143-A | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5488047-A | HYPOTENSIVE AGENTS, ANALGESICS; CONGESTIVE HEART FAILURE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-30 | — | — | US | disclosed |
| US-5472959-A | Hypotensive agents, congestive heart failure | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-12-05 | — | — | US | disclosed |
| US-5457196-A | Analgesics, hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-10-10 | — | — | US | disclosed |
| US-5455242-A | Analgesics, hypotensive or cardiotonic agents, diuretics, antidepressants or suppressors of vascular response after angioplasty | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5430145-A | Analgesics, reduction of drug withdrawal symptoms, hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5428158-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0534396-A2 | 2-Substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| EP-0534492-A2 | Carboxyalkyl substituted inhibitors of enkephalinase and ACE | MERRELL PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| EP-0534363-A2 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| EP-0481522-A1 | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1992-04-22 | — | — | EP | disclosed |
| EP-0249224-A2 | Novel antihypertensive agent | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-12-16 | — | — | EP | disclosed |