Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.45 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288310 | 0.90 | TSHR (0.44) | CYP3A4LMNAHTTTSHRABCB11 | |
| SCHEMBL10509805 | 0.87 | ACE (0.47) | LMNATSHRMEN1KMT2AACE | |
| SCHEMBL10858951 | 0.84 | ACE (0.43) | LMNATSHRMEN1KMT2AACE | |
| SCHEMBL10512983 | 0.83 | SMN1; SMN2 (0.47) | LMNAHTTKCNH2THRBACE | |
| SCHEMBL10509803 | 0.83 | PDPK1 (0.47) | CACNA1CTHRBACEMMEGSK3B | |
| SCHEMBL10860777 | 0.78 | LMNA (0.50) | CYP3A4LMNAHTTTSHRABCB11 | |
| SCHEMBL10651624 | 0.75 | NPSR1 (0.58) | HTTTSHRNPSR1GSK3B | |
| SCHEMBL10506983 | 0.75 | SMN1; SMN2 (0.47) | LMNATSHRMEN1KMT2AACE | |
| SCHEMBL7280075 | 0.75 | POLB (0.46) | CYP3A4LMNAHTTTSHRMEN1 | |
| SCHEMBL7288638 | 0.75 | PDPK1 (0.44) | CYP3A4LMNAHTTTSHRABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4584300-A | Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1986-04-22 | — | — | US | disclosed |
| EP-0116368-A1 | Benzothiazine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-22 | — | — | EP | disclosed |