Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10616241 | 0.82 | CYP3A4 (0.58) | GSTO1ALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL30149406 | 0.80 | GSTO1 (0.56) | GSTO1ALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL29103848 | 0.80 | GSTO1 (0.56) | GSTO1ALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL30149351 | 0.79 | GSTO1 (0.54) | GSTO1ALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL29103846 | 0.79 | GSTO1 (0.54) | GSTO1ALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL8125102 | 0.77 | MEN1 (0.69) | GSTO1ALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL29263285 | 0.75 | GSTO1 (0.57) | GSTO1ALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL9081388 | 0.74 | NPC1 (0.76) | GSTO1ALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL1031451 | 0.74 | HDAC3 (0.60) | ALDH1A1SMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL7282083 | 0.74 | KMT2A (0.58) | ALDH1A1SMN1; SMN2HTTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |