Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.39 |
| ▸ | HRH2 | P25021 | 10/20 | 0.39 |
| ▸ | HRH1 | P35367 | 10/20 | 0.39 |
| ▸ | MMP2 | P08253 | 5/20 | 0.39 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282332 | 0.89 | HRH3 (0.40) | HRH3HRH2HRH1MEN1KMT2A | |
| SCHEMBL7272780 | 0.87 | MEN1 (0.39) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7275661 | 0.85 | HRH3 (0.39) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7283176 | 0.84 | MMP2 (0.43) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7282997 | 0.83 | POLB (0.40) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7275831 | 0.83 | MMP2 (0.39) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7285068 | 0.83 | HRH3 (0.41) | HRH3HRH2HRH1MMP2MEN1 | |
| SCHEMBL7276110 | 0.83 | PGR (0.39) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7282428 | 0.82 | HRH3 (0.42) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7273794 | 0.82 | MAOB (0.39) | HRH3HRH2HRH1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |