Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.62 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ADH1B | P00325 | 1/20 | 0.35 |
| ▸ | ADH1C | P00326 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 1/20 | 0.35 |
| ▸ | ADH4 | P08319 | 1/20 | 0.35 |
| ▸ | ADH7 | P40394 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792344 | 0.91 | EPHX1 (0.46) | EPHX1TSHRALDH1A1ADH1BADH1C | |
| SCHEMBL1793038 | 0.91 | EPHX1 (0.46) | EPHX1TSHRALDH1A1ADH1BADH1C | |
| SCHEMBL1793351 | 0.91 | EPHX1 (0.46) | EPHX1TSHRALDH1A1ADH1BADH1C | |
| SCHEMBL177856 | 0.89 | TSHR (0.46) | EPHX1TSHRALDH1A1ADH1BADH1C | |
| SCHEMBL10566376 | 0.87 | EPHX1 (0.40) | EPHX1TSHRALDH1A1ADH1BADH1C | |
| SCHEMBL11154609 | 0.84 | TSHR (0.39) | EPHX1TSHRALDH1A1ADH1BADH1C | |
| SCHEMBL24908635 | 0.79 | EPHX1 (1.00) | EPHX1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL22876 | 0.79 | EPHX1 (1.00) | EPHX1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL577733 | 0.79 | EPHX1 (1.00) | EPHX1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL25273267 | 0.79 | EPHX1 (1.00) | EPHX1S1PR2S1PR4S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422937-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1994-03-02 | — | — | EP | claimed |
| EP-0422938-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5374622-A | Modified cyclic heptapeptides | MERCK & CO., INC. (US) | 1994-12-20 | — | — | US | disclosed |
| US-5338723-A | Anticoagulants and thrombus preventatives comprising cyclic hexapeptides having a synthetic amino acid replace arginine in the sequence of arginine/glycine/aspartic acid | MERCK & CO., INC. (US) | 1994-08-16 | — | — | US | disclosed |
| EP-0422937-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1994-03-02 | — | — | EP | disclosed |
| EP-0422938-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1991-04-17 | — | — | EP | disclosed |
| EP-0422937-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1991-04-17 | — | — | EP | disclosed |