SCHEMBL728208

SCHEMBL728208

COC(=O)C(=O)CC(=O)c1c(OC)cccc1OC

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA7 P43166 1/20 0.53
CA9 Q16790 1/20 0.53
CA14 Q9ULX7 1/20 0.53
TAAR1 Q96RJ0 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.43
TSHR P16473 1/20 0.43
NPC1 O15118 1/20 0.42
CTSD P07339 1/20 0.42
KMT2A Q03164 2/20 0.42
MAPT P10636 1/20 0.42
ATM Q13315 1/20 0.42
KCNH2 Q12809 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17114462 0.98 CA12 (0.52) CA12CA1CA2CA7CA9
SCHEMBL17317414 0.87 TSHR (0.52) CA12CA1CA2CA7CA9
SCHEMBL28295322 0.86 CA12 (0.58) CA12CA1CA2CA7CA9
SCHEMBL27861005 0.81 CA12 (0.57) CA12CA1CA2CA7CA9
SCHEMBL19849257 0.81 CA12 (0.57) CA12CA1CA2CA7CA9
SCHEMBL29819654 0.81 NPC1 (0.66) SMN1; SMN2NPC1CTSDKMT2A
SCHEMBL20239567 0.81 NPC1 (0.66) SMN1; SMN2NPC1CTSDKMT2A
SCHEMBL28035202 0.80 FEN1 (0.43) CA12CA1CA2CA7CA9
SCHEMBL17114470 0.79 NPC1 (0.64) SMN1; SMN2NPC1CTSDKMT2A
SCHEMBL17114471 0.79 NPC1 (0.64) SMN1; SMN2NPC1CTSDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250026739-A1 COMPOUNDS AND RADIOLIGANDS FOR TARGETING NEUROTENSIN RECEPTOR AND USES THEREOF FULL-LIFE TECHNOLOGIES HK LIMITED (CN) 2025-01-23 US disclosed
EP-4479040-A1 COMPOUNDS AND RADIOLIGANDS FOR TARGETING NEUROTENSIN RECEPTOR AND USES THEREOF Full-Life Technologies HK Limited (HK) 2024-12-25 EP disclosed
CN-119136796-A Neurotensin receptor-targeting compounds and radioligands and uses thereof 辐联科技香港有限公司 2024-12-13 CN disclosed
US-12145926-B2 Compounds and radioligands for targeting neurotensin receptor and uses thereof FULL-LIFE TECHNOLOGIES HK LIMITED (CN) 2024-11-19 US disclosed
US-20240287046-A1 COMPOUNDS AND RADIOLIGANDS FOR TARGETING NEUROTENSIN RECEPTOR AND USES THEREOF FULL-LIFE TECHNOLOGIES HK LIMITED (CN) 2024-08-29 US disclosed
WO-2023158802-A1 COMPOUNDS AND RADIOLIGANDS FOR TARGETING NEUROTENSIN RECEPTOR AND USES THEREOF FULL-LIFE TECHNOLOGIES U.S. INC. (US) 2023-08-24 WO disclosed
WO-2023158802-A1 COMPOUNDS AND RADIOLIGANDS FOR TARGETING NEUROTENSIN RECEPTOR AND USES THEREOF FULL-LIFE TECHNOLOGIES U.S. INC. (US) 2023-08-24 WO disclosed
CN-109790152-B Diagnosis, treatment and prevention of neurotensin receptor-related disorders 埃朗根-纽伦堡 弗里德里希-亚历山大大学 2022-05-24 CN disclosed
US-11180511-B2 Diagnosis, treatment and prevention of neurotensin receptor-related conditions FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG; UNIVERSITÄTSKLINIKUM ERLANGEN (DE) 2021-11-23 US disclosed
EP-3494114-B1 DIAGNOSIS, TREATMENT AND PREVENTION OF NEUROTENSIN RECEPTOR-RELATED CONDITIONS UNIV FRIEDRICH ALEXANDER ER (DE) 2020-12-23 EP disclosed
EP-3494114-B1 DIAGNOSIS, TREATMENT AND PREVENTION OF NEUROTENSIN RECEPTOR-RELATED CONDITIONS UNIV FRIEDRICH ALEXANDER ER (DE) 2020-12-23 EP disclosed
US-20200377523-A1 DIAGNOSIS, TREATMENT AND PREVENTION OF NEUROTENSIN RECEPTOR-RELATED CONDITIONS Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) 2020-12-03 US disclosed
EP-3494114-A1 DIAGNOSIS, TREATMENT AND PREVENTION OF NEUROTENSIN RECEPTOR-RELATED CONDITIONS Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) 2019-06-12 EP disclosed
WO-2018024789-A1 DIAGNOSIS, TREATMENT AND PREVENTION OF NEUROTENSIN RECEPTOR-RELATED CONDITIONS Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) 2018-02-08 WO disclosed
EP-3279197-A1 DIAGNOSIS, TREATMENT AND PREVENTION OF NEUROTENSIN RECEPTOR-RELATED CONDITIONS Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) 2018-02-07 EP disclosed
WO-2011156557-A2 COMPOUNDS ACTIVE AT THE NEUROTENSIN RECEPTOR THOMAS JAMES B (US) 2011-12-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250026739-A1 COMPOUNDS AND RADIOLIGANDS FOR TARGETING NEUROTENSIN RECEPTOR AND USES THEREOF NTSR1, NTSR2, NPSR1 CA12 300/4885CA1 651/4885CA2 820/4885
US-20240287046-A1 COMPOUNDS AND RADIOLIGANDS FOR TARGETING NEUROTENSIN RECEPTOR AND USES THEREOF NTSR1, NTSR2, NPSR1 CA12 247/4885CA1 545/4885CA2 821/4885
US-11180511-B2 Diagnosis, treatment and prevention of neurotensin receptor-related conditions NTSR1, NTSR2, NPSR1 CA12 280/4885CA1 1342/4885CA2 973/4885
US-12145926-B2 Compounds and radioligands for targeting neurotensin receptor and uses thereof NTSR1, NTSR2, NPSR1 CA12 247/4885CA1 545/4885CA2 821/4885
US-20200377523-A1 DIAGNOSIS, TREATMENT AND PREVENTION OF NEUROTENSIN RECEPTOR-RELATED CONDITIONS NTSR1, NTSR2, NPSR1 CA12 280/4885CA1 1342/4885CA2 973/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.