Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275502 | 0.90 | S1PR1 (0.44) | S1PR1ITGB3ITGA2BHDAC1HPGD | |
| SCHEMBL7275936 | 0.84 | ITGB3 (0.52) | S1PR1ITGB3ITGA2BHDAC1FFAR1 | |
| SCHEMBL7276092 | 0.80 | ITGB3 (0.46) | S1PR1ITGB3ITGA2BHDAC1L3MBTL1 | |
| SCHEMBL7274080 | 0.78 | ITGB3 (0.74) | S1PR1ITGB3ITGA2B | |
| SCHEMBL7274915 | 0.78 | S1PR1 (0.54) | S1PR1ITGB3ITGA2BHDAC1S1PR3 | |
| SCHEMBL7274246 | 0.74 | S1PR1 (0.52) | S1PR1ITGB3ITGA2BHDAC1L3MBTL1 | |
| SCHEMBL8417146 | 0.74 | S1PR1 (0.83) | S1PR1HDAC1FFAR1FFAR4 | |
| Propylamine SCHEMBL8911584 | 0.74 | S1PR1 (0.55) | S1PR1ITGB3ITGA2BL3MBTL1FFAR1 | |
| SCHEMBL7271946 | 0.74 | ITGB3 (0.63) | S1PR1ITGB3ITGA2B | |
| SCHEMBL7284477 | 0.74 | ITGB3 (0.70) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |