Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | USP14 | P54578 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282967 | 1.00 | CYP11B1 (0.44) | CYP11B1CYP11B2KDM4EUSP14MEN1 | |
| Hydrochloric Acid SCHEMBL7281759 | 0.82 | ITGB3 (0.41) | MAPTHRH3 | |
| Hydrochloric Acid SCHEMBL7283833 | 0.82 | ITGB3 (0.41) | MAPTHRH3 | |
| SCHEMBL7275677 | 0.80 | CYP11B1 (0.44) | CYP11B1CYP11B2KDM4EUSP14MEN1 | |
| SCHEMBL7282714 | 0.80 | CYP11B1 (0.44) | CYP11B1CYP11B2KDM4EUSP14MEN1 | |
| SCHEMBL7385642 | 0.79 | PDE3B (0.39) | KDM4ETDP1HRH3ALDH1A1 | |
| SCHEMBL7281781 | 0.78 | CYP11B1 (0.44) | CYP11B1CYP11B2KDM4EMEN1KMT2A | |
| SCHEMBL7283880 | 0.78 | CYP11B1 (0.44) | CYP11B1CYP11B2KDM4EMEN1KMT2A | |
| SCHEMBL3628694 | 0.78 | CYP11B1 (0.56) | CYP11B1CYP11B2MEN1KMT2AMAPT | |
| SCHEMBL7281800 | 0.78 | CYP11B1 (0.42) | CYP11B1CYP11B2KDM4EUSP14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |