Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985915 | 0.79 | HSD17B10 (0.50) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL22842957 | 0.78 | L3MBTL1 (0.54) | LMNASMN1; SMN2NPC1MITFTP53 | |
| SCHEMBL9760318 | 0.77 | HSD17B10 (0.48) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL28411775 | 0.76 | POLB (0.38) | LMNASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL5179848 | 0.76 | GAA (0.40) | LMNARAB9AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL28748119 | 0.76 | KDM4E (0.56) | LMNASMN1; SMN2NPC1MITFTP53 | |
| SCHEMBL2851306 | 0.75 | ALDH1A1 (0.55) | LMNARAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL8147814 | 0.75 | POLB (0.38) | LMNASMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL10966316 | 0.75 | ALDH1A1 (0.59) | LMNASMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL9752736 | 0.74 | L3MBTL1 (0.60) | LMNASMN1; SMN2NPC1MITFTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4568677-A | CONTROLLED COOLING | PFIZER INC. (US) | 1986-02-04 | — | — | US | disclosed |
| EP-0132375-A2 | Dihydropyridine anti-ischaemic and antihypertensive agents | Pfizer Limited (GB) | 1985-01-30 | — | — | EP | disclosed |