SCHEMBL7283233

SCHEMBL7283233

Cc1c[c]c(OCc2ccccc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.46
MAPT P10636 2/20 0.46
MAPK1 P28482 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
LMNA P02545 2/20 0.41
GAA P10253 2/20 0.41
POLB P06746 1/20 0.41
HTT P42858 3/20 0.40
NPC1 O15118 1/20 0.40
CYP1A2 P05177 1/20 0.39
PTGS1 P23219 1/20 0.39
SLC6A2 P23975 1/20 0.39
CYP2C19 P33261 1/20 0.39
PTGS2 P35354 1/20 0.39
SLC6A3 Q01959 1/20 0.39
HIF1A Q16665 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
TSHR P16473 1/20 0.39
MAOB P27338 2/20 0.39
LIPE Q05469 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10414960 0.80 LMNA (0.53) L3MBTL1MAPTMAPK1TDP1LMNA
SCHEMBL3070157 0.80 LMNA (0.53) L3MBTL1MAPTLMNAGAACYP1A2
SCHEMBL6201495 0.79 MAOB (0.51) L3MBTL1MAPTLMNAGAAHTT
SCHEMBL28151052 0.79 MAOB (0.55) L3MBTL1MAPTMAPK1TDP1LMNA
SCHEMBL3609423 0.79 MAOB (0.46) L3MBTL1MAPTMAPK1TDP1LMNA
SCHEMBL27822827 0.79 APP (0.50) L3MBTL1MAPTMAPK1TDP1LMNA
SCHEMBL11687714 0.79 AGXT (0.44) L3MBTL1MAPTMAPK1TDP1LMNA
SCHEMBL511881 0.79 BCHE (0.40) L3MBTL1MAPTMAPK1TDP1LMNA
SCHEMBL17698456 0.79 MAPT (0.42) L3MBTL1MAPTMAPK1TDP1LMNA
SCHEMBL29167670 0.78 BCHE (0.39) L3MBTL1MAPTMAPK1TDP1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4029690-A WITH 2,5-DIMETHYL-2,4-HEXADIENE AND AN ALKYL DIAZOACETATE WITH A COPPER COMPLEX CATALYST SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-06-14 US claimed
US-4029683-A WITH A SCHIFF BASE, CHRYSANTHEMATE SYNTHESIS CATALYST SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-06-14 US claimed
CN-110372571-B 2- (2, 2-diarylethyl) -cyclic amine derivative or salt, synthesis and application thereof, and composition 中国科学院大连化学物理研究所 2022-11-15 CN disclosed
CN-113226464-A N- (pyridin-2-ylsulfonyl) cyclopropanecarboxamide derivatives and their use in the treatment of CFTR mediated diseases 诺华股份有限公司 2021-08-06 CN disclosed
CN-110372571-A A kind of 2- (2,2- diaryl ethyl)-Cycloamine derivative or salt and synthesis and application and composition 中国科学院大连化学物理研究所 2019-10-25 CN disclosed
EP-0641786-B1 Process for producing optically active alcohol SUMITOMO CHEMICAL CO (JP) 1997-08-20 EP disclosed
EP-0381434-B1 Process for producing optically active alcohol SUMITOMO CHEMICAL CO (JP) 1997-04-16 EP disclosed
EP-0435687-B1 Process for isomerization of oxime ethers SUMITOMO CHEMICAL CO (JP) 1995-03-29 EP disclosed
EP-0641786-A1 Process for producing optically active alcohol SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-03-08 EP disclosed
EP-0485069-B1 Process for producing optically active amines SUMITOMO CHEMICAL CO (JP) 1995-02-15 EP disclosed
EP-0347766-B1 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments THOMAE GMBH DR K (DE) 1994-05-25 EP disclosed
EP-0022608-B1 PROCESS FOR THE PREPARATION OF CYCLOPROPANE CARBOXYLIC ACID ESTERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-07-06 EP disclosed
US-4344894-A TRANSITION METAL COMPLEX OF SCHIFF BASES AS CATALYSTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-08-17 US disclosed
US-4343935-A CATALYSTS FOR CYCLOPROPANIZATION OF OLEFINS BY DIAZOACETATES IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-08-10 US disclosed
US-4288387-A REACTION OF A HALOGENOPENTENE OR HEXENE WITH A DIAZOACETIC ESTER IN THE PRESENCE OF CATALYST WHICH IS METALLIC COPPER, A COPPER SALT, A RHODIUM SALT, OR A TRANSITION METAL COMPLEX OF A CHIRAL SCHIFF BASE IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-09-08 US disclosed
EP-0023075-A1 Process for the preparation of cyclopropane carboxylic acid esters IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-01-28 EP disclosed
EP-0022608-A1 Process for the preparation of cyclopropane carboxylic acid esters IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-01-21 EP disclosed
US-4197408-A COPPER COMPLEX CATALYST, 2,5-DIMETHYL-2,4-HEXADIEN) REACTED WITH DIAZOACETATE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1980-04-08 US disclosed
US-4029690-A WITH 2,5-DIMETHYL-2,4-HEXADIENE AND AN ALKYL DIAZOACETATE WITH A COPPER COMPLEX CATALYST SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-06-14 US disclosed
US-4029683-A WITH A SCHIFF BASE, CHRYSANTHEMATE SYNTHESIS CATALYST SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-06-14 US disclosed