⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2994249 | 0.69 | — | — | |
| SCHEMBL29323797 | 0.65 | — | — | |
| SCHEMBL27490888 | 0.63 | — | — | |
| SCHEMBL2134249 | 0.60 | — | — | |
| SCHEMBL10588812 | 0.59 | — | — | |
| SCHEMBL30712743 | 0.59 | — | — | |
| SCHEMBL11720477 | 0.58 | — | — | |
| SCHEMBL7834439 | 0.58 | — | — | |
| SCHEMBL14846362 | 0.56 | — | — | |
| SCHEMBL31265539 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238264-A1 | INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF | DISARM THERAPEUTICS, INC. | 2024-07-18 | — | — | US | disclosed |
| US-20240238264-A1 | INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF | DISARM THERAPEUTICS, INC. | 2024-07-18 | — | — | US | disclosed |
| US-11253503-B2 | Inhibitors of SARM1 NADase activity and uses thereof | WASHINGTON UNIVERSITY (US) | 2022-02-22 | — | — | US | disclosed |
| US-11142545-B2 | Synthesis of thiolated oligonucleotides without a capping step | BIOGEN MA INC. (US) | 2021-10-12 | — | — | US | disclosed |
| US-20200129493-A1 | INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF | WASHINGTON UNIVERSITY (US) | 2020-04-30 | — | — | US | disclosed |
| US-20190161513-A1 | SYNTHESIS OF THIOLATED OLIGONUCLEOTIDES WITHOUT A CAPPING STEP | BIOGEN MA INC. | 2019-05-30 | — | — | US | disclosed |
| WO-2018057989-A1 | INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF | WASHINGTON UNIVERSITY (US) | 2018-03-29 | — | — | WO | disclosed |
| US-20130302679-A1 | RECHARGEABLE BATTERY, FUNCTIONAL POLYMER, AND METHOD FOR SYNTHESIS THEREOF | POLYTHIONE CO. LTD (JP) | 2013-11-14 | — | — | US | disclosed |
| WO-2011152471-A2 | RECHARGEABLE BATTERY, FUNCTIONAL POLYMER, AND METHOD FOR SYNTHESIS THEREOF | 株式会社ポリチオン (JP) | 2011-12-08 | — | — | WO | disclosed |
| US-4010199-A | Miticidal dithiobiurets | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-03-01 | — | — | US | disclosed |
| US-3944670-A | Pesticidal dithiazolium salts | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-03-16 | — | — | US | disclosed |