Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6225122 | 0.82 | GAA (0.60) | KDM4EMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL11509284 | 0.81 | MAPT (1.00) | KDM4EMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL13736441 | 0.80 | MAPT (0.57) | KDM4EMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL9577809 | 0.78 | MAPT (0.55) | KDM4EMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL5305854 | 0.77 | L3MBTL1 (0.70) | ALDH1A1MAPTNPC1MTORRAB9A | |
| SCHEMBL28927027 | 0.76 | MAPT (0.53) | KDM4EMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL2204571 | 0.74 | KDM4E (0.52) | KDM4EMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL6261878 | 0.74 | MAPT (0.88) | KDM4EMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL3879346 | 0.74 | MAPK1 (0.46) | KDM4EMEN1ALDH1A1MAPTALOX12 | |
| SCHEMBL8650828 | 0.74 | RAB9A (0.82) | MEN1ALDH1A1MAPTTHRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8137688-B2 | Hydroxyphenyl cross-linked macromolecular network and applications thereof | THE CLEVELAND CLINIC FOUNDATION (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138265-B2 | Hydroxyphenyl cross-linked macromolecular network and applications thereof | THE CLEVELAND CLINIC FOUNDATION (US) | 2012-03-20 | — | — | US | disclosed |
| US-8021350-B2 | Hydroxyphenyl cross-linked macromolecular network and applications thereof | THE CLEVELAND CLINIC FOUNDATION (US) | 2011-09-20 | — | — | US | disclosed |