Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.74 |
| ▸ | MTOR | P42345 | 2/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.74 |
| ▸ | MLNR | O43193 | 1/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.74 |
| ▸ | CNR1 | P21554 | 1/20 | 0.74 |
| ▸ | HRH1 | P35367 | 1/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272697 | 0.98 | ADORA3 (0.73) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL7272469 | 0.95 | CYP1A2 (0.78) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL10411083 | 0.94 | ADORA3 (0.66) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL10411081 | 0.94 | ADORA3 (0.66) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL7275429 | 0.90 | CACNA1C (0.70) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL10409941 | 0.90 | CACNA1C (0.69) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL10409943 | 0.90 | CACNA1C (0.69) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL7274431 | 0.89 | CYP1A2 (0.70) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL7275141 | 0.88 | ADORA3 (0.75) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL7274957 | 0.88 | CYP1A2 (0.70) | ADORA3ADRA1AMTORRAB9ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153016-A2 | Asymmetrical diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1985-08-28 | — | — | EP | claimed |
| US-4772621-A | Antihypertensive diphenylpropyl aminopropyl ester of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1988-09-20 | — | — | US | disclosed |
| US-4705797-A | HYPOTENSIVE AGENTS, VASODILATORS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1987-11-10 | — | — | US | disclosed |
| EP-0153016-A2 | Asymmetrical diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1985-08-28 | — | — | EP | disclosed |