Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924917 | 0.73 | NOTUM (0.62) | POLBHTTNOTUMKDM4EGLA | |
| SCHEMBL24843674 | 0.71 | NOTUM (0.41) | POLBHTTNOTUMKDM4EMEN1 | |
| SCHEMBL13172044 | 0.70 | MTNR1A (0.55) | POLBHTTMTNR1AKDM4EALDH1A1 | |
| SCHEMBL27670765 | 0.68 | KDM4E (0.47) | POLBMTNR1AKDM4EGLAGAA | |
| SCHEMBL8157626 | 0.67 | POLB (0.36) | POLBHTTKDM4EMEN1KMT2A | |
| SCHEMBL7290719 | 0.67 | HTR1D (0.52) | POLBHTTKDM4EGLAGAA | |
| SCHEMBL28550833 | 0.66 | TUBB1 (0.62) | POLBNOTUMMTNR1AKDM4EALDH1A1 | |
| SCHEMBL31316141 | 0.66 | TUBB1 (0.62) | POLBNOTUMMTNR1AKDM4EALDH1A1 | |
| SCHEMBL29518325 | 0.66 | TUBB4A (0.49) | POLBHTTKDM4EGLAGAA | |
| SCHEMBL27593738 | 0.66 | TUBB4A (0.49) | POLBHTTKDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343574-B1 | 4(1H)-quinolone derivatives | KIRIN BREWERY (JP) | 1994-07-27 | — | — | EP | claimed |
| EP-0343574-B1 | 4(1H)-quinolone derivatives | KIRIN BREWERY (JP) | 1994-07-27 | — | — | EP | disclosed |
| US-5081121-A | Cardiotonic agents | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0343574-A1 | 4(1H)-quinolone derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1989-11-29 | — | — | EP | disclosed |