Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287209 | 0.88 | SPHK1 (0.34) | SPHK1HCRTR2 | |
| SCHEMBL5495814 | 0.82 | SPHK1 (0.35) | SPHK1HCRTR2 | |
| SCHEMBL8112149 | 0.82 | SPHK1 (0.35) | SPHK1HCRTR2 | |
| SCHEMBL8145278 | 0.82 | SPHK1 (0.35) | SPHK1HCRTR2 | |
| SCHEMBL8112146 | 0.82 | SPHK1 (0.35) | SPHK1HCRTR2 | |
| SCHEMBL10378982 | 0.82 | SPHK1 (0.33) | SPHK1 | |
| SCHEMBL7287047 | 0.82 | SPHK1 (0.35) | SPHK1 | |
| SCHEMBL7287051 | 0.82 | SPHK1 (0.35) | SPHK1 | |
| SCHEMBL5833363 | 0.80 | KLK7 (0.40) | — | |
| SCHEMBL7962411 | 0.80 | KLK7 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0264106-B1 | 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use | BANYU PHARMA CO LTD (JP) | 1994-03-16 | — | — | EP | disclosed |
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| EP-0272583-B1 | 5-SUBSTITUTED AMINO-4-HYDROXY-PENTENOIC ACID DERIVATIVES AND THEIR USE | Banyu Pharmaceutical Co., Ltd. (JP) | 1993-09-15 | — | — | EP | disclosed |
| US-4927565-A | HYPOTENSIVE AGENT | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1990-05-22 | — | — | US | disclosed |
| US-4864017-A | Novel renin inhibiting peptides having a dihyroxyethylene isostere transition state insert | THE UPJOHN COMPANY (US) | 1989-09-05 | — | — | US | disclosed |
| US-4851387-A | RENIN INHIBITORS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0272583-A2 | 5-Substituted amino-4-hydroxy-pentenoic acid derivatives and their use | Banyu Pharmaceutical Co., Ltd. (JP) | 1988-06-29 | — | — | EP | disclosed |
| EP-0264106-A2 | 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use | Banyu Pharmaceutical Co., Ltd. (JP) | 1988-04-20 | — | — | EP | disclosed |
| EP-0237202-A2 | Novel renin inhibiting peptides having a dihydroxyethylene isostere transition state insert | THE UPJOHN COMPANY (US) | 1987-09-16 | — | — | EP | disclosed |