SCHEMBL7962411

SCHEMBL7962411

CC(C)(C)OC(=O)N1[C@H](Cc2ccccc2)[C@@H](C=O)OC1(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KLK7 P49862 7/20 0.40
KLK5 Q9Y337 6/20 0.38
CYP3A4 P08684 3/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 1/20 0.38
PRSS1 P07477 3/20 0.37
PRSS2 P07478 3/20 0.37
PRSS3 P35030 3/20 0.37
ABCB1 P08183 1/20 0.37
GPR119 Q8TDV5 1/20 0.36
STS P08842 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
KDM4E B2RXH2 1/20 0.35
PKM P14618 1/20 0.35
ALOX15 P16050 1/20 0.35
MAPK1 P28482 1/20 0.35
HPGD P15428 1/20 0.35
NR1H2 P55055 2/20 0.35
NR1H3 Q13133 2/20 0.35
KEAP1 Q14145 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5833363 1.00 KLK7 (0.40) KLK7KLK5CYP3A4ALDH1A1MAPT
SCHEMBL2175307 1.00 KLK7 (0.40) KLK7KLK5CYP3A4ALDH1A1MAPT
SCHEMBL2175304 1.00 KLK7 (0.40) KLK7KLK5CYP3A4ALDH1A1MAPT
SCHEMBL7270587 0.91 KLK7 (0.41) KLK7KLK5CYP3A4ALDH1A1MAPT
SCHEMBL7279540 0.89 KLK7 (0.38) KLK7KLK5CYP3A4ALDH1A1MAPT
SCHEMBL7360985 0.89 MAPT (0.38) CYP3A4ALDH1A1MAPTSTSSMN1; SMN2
SCHEMBL7270189 0.89 KLK7 (0.38) KLK7KLK5CYP3A4ALDH1A1MAPT
SCHEMBL7279530 0.89 KLK7 (0.38) KLK7KLK5CYP3A4ALDH1A1MAPT
SCHEMBL7270193 0.89 KLK7 (0.38) KLK7KLK5CYP3A4ALDH1A1MAPT
SCHEMBL7950824 0.88 KLK7 (0.37) KLK7KLK5CYP3A4ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6271238-B1 USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2001-08-07 US disclosed
EP-0936216-A1 NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1999-08-18 EP disclosed
EP-0454302-A2 Tuftsin derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1991-10-30 EP disclosed