SCHEMBL7284331

SCHEMBL7284331

[CH2]CCCCC(C#N)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 4/20 0.41
TRPA1 O75762 1/20 0.39
TSHR P16473 1/20 0.39
HRH1 P35367 4/20 0.35
HTR2A P28223 3/20 0.35
ESR1 P03372 3/20 0.33
ESR2 Q92731 3/20 0.33
ALDH1A1 P00352 2/20 0.33
SIGMAR1 Q99720 2/20 0.33
MEN1 O00255 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33
CNR1 P21554 1/20 0.32
PBRM1 Q86U86 1/20 0.32
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
NPC1 O15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7296087 0.94 CCR1 (0.42) CCR1TRPA1TSHRHRH1HTR2A
SCHEMBL7295721 0.86 TRPA1 (0.43) CCR1TRPA1TSHRHRH1HTR2A
SCHEMBL11151613 0.81 CCR1 (0.41) CCR1TRPA1TSHRHRH1HTR2A
SCHEMBL1310360 0.81 CCR1 (0.41) CCR1TRPA1TSHRHRH1HTR2A
SCHEMBL10451727 0.81 CCR1 (0.43) CCR1TRPA1TSHRHRH1HTR2A
SCHEMBL1846324 0.81 CCR1 (0.46) CCR1TRPA1TSHRHRH1HTR2A
SCHEMBL10865835 0.81 ESR1 (0.31) CCR1ESR1ESR2ALDH1A1MEN1
SCHEMBL7309655 0.80 HTR2A (0.41) CCR1TRPA1TSHRHRH1HTR2A
SCHEMBL7108521 0.80 CCR1 (0.40) CCR1TRPA1TSHRHRH1HTR2A
SCHEMBL7754790 0.80 HTR2A (0.41) CCR1TRPA1TSHRHRH1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0067461-B1 PREPARATION OF CYANOBENZYL CYCLOPROPANE CARBOXYLATES SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1985-07-17 EP claimed
US-4409150-A ESTERIFICATION SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1983-10-11 US claimed
EP-0067461-A1 Preparation of cyanobenzyl cyclopropane carboxylates SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1982-12-22 EP claimed
US-5306719-A Cardiotonic agents OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-04-26 US disclosed
EP-0255134-B1 CARBOSTYRIL DERIVATIVES AND SALTS THEREOF, PROCESS FOR PREPARING THEM, AND CARDIOTONIC COMPOSITION CONTAINING SAME OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1993-03-03 EP disclosed
US-5071856-A CARBOSTYRIL DERIVATIVES AND SALTS THEREOF OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1991-12-10 US disclosed
US-4886809-A CARDIOTONIC AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1989-12-12 US disclosed
EP-0255134-A2 Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1988-02-03 EP disclosed
EP-0067461-B1 PREPARATION OF CYANOBENZYL CYCLOPROPANE CARBOXYLATES SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1985-07-17 EP disclosed
US-4409150-A ESTERIFICATION SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1983-10-11 US disclosed
US-4409150-A ESTERIFICATION SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1983-10-11 US disclosed
EP-0067461-A1 Preparation of cyanobenzyl cyclopropane carboxylates SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1982-12-22 EP disclosed
EP-0067461-A1 Preparation of cyanobenzyl cyclopropane carboxylates SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1982-12-22 EP disclosed