Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276703 | 0.85 | HTT (0.43) | GABRA1GABRB2MEN1KMT2AGABRB1 | |
| SCHEMBL25069322 | 0.77 | GABRA1 (0.54) | GABRA1GABRB2MEN1KMT2AGABRB1 | |
| SCHEMBL25069375 | 0.76 | GABRA1 (0.53) | GABRA1GABRB2MEN1KMT2AGABRB1 | |
| SCHEMBL15999525 | 0.75 | GABRA1 (0.52) | GABRA1GABRB2MEN1KMT2AGABRB1 | |
| SCHEMBL23731297 | 0.74 | GABRA1 (0.51) | GABRA1GABRB2MEN1KMT2AGABRB1 | |
| SCHEMBL29027116 | 0.74 | GABRA1 (0.51) | GABRA1GABRB2MEN1KMT2AGABRB1 | |
| SCHEMBL29550066 | 0.74 | GABRA1 (0.51) | GABRA1GABRB2MEN1KMT2AGABRB1 | |
| SCHEMBL7283404 | 0.74 | ALDH1A1 (0.51) | GABRA1GABRB2MEN1KMT2AGABRB1 | |
| SCHEMBL10867026 | 0.74 | GABRA1 (0.53) | GABRA1GABRB2MEN1KMT2AGABRB1 | |
| SCHEMBL14842825 | 0.73 | GABRA1 (0.50) | GABRA1GABRB2MEN1KMT2AGABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0516392-A2 | Naphthyridine derivatives as angiotensin II inhibitors | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |