Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1253094 | 0.81 | TRIM24 (0.37) | TRIM24TRIM33ALDH1A1CYP2A6ATM | |
| SCHEMBL3554228 | 0.79 | TRIM24 (0.36) | TRIM24TRIM33ALDH1A1CYP2A6ATM | |
| SCHEMBL21335550 | 0.79 | PTGER4 (0.44) | ALDH1A1ERN1CYP2A6CCR2PTGER4 | |
| SCHEMBL7292558 | 0.77 | FBP1 (0.43) | ALDH1A1POLBHTT | |
| SCHEMBL7292564 | 0.77 | FBP1 (0.43) | ALDH1A1POLBHTT | |
| SCHEMBL18000433 | 0.74 | CMA1 (0.37) | ALDH1A1CYP2A6CCR2PCSK9HRH4 | |
| SCHEMBL2572438 | 0.73 | JAK2 (0.35) | ALDH1A1CCR2PCSK9HRH4JAK2 | |
| SCHEMBL342762 | 0.71 | GRIN2D (0.51) | ALDH1A1DAO | |
| SCHEMBL29894136 | 0.71 | GRIN2D (0.51) | ALDH1A1DAO | |
| SCHEMBL9367162 | 0.69 | CA12 (0.50) | ALDH1A1JAK2BTKDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | disclosed |
| US-5183820-A | Useful for treatment of nausea, vomiting, irritable bowel syndrome and dyspepsia | GLAXO GROUP LIMITED (GB) | 1993-02-02 | — | — | US | disclosed |
| EP-0353983-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-02-07 | — | — | EP | disclosed |